Microwave synthesis of difficult peptides

Traditional solid phase synthesis of peptides is a very time-consuming reaction. In order to improve the yield, it is usually carried out under the conditions of blowing N2 or vortex mixing. Some laboratories raise the synthesis temperature to about 60 ° C, and this measure will reduce the chain polymerization phenomenon while causing new side reactions. Recently, biochemists have discovered that the intervention of microwave solves the contradiction between maintaining a certain temperature and increasing the energy input in peptide synthesis. The use of microwaves for solid-phase peptide synthesis can effectively shorten the reaction time while greatly mentioning the purity and yield of the product.

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