"Nature" editorial focuses on human genome sequencing

The "Nature" magazine published on February 10 published an editorial-"Best is yet to come" (Best is yet to come), reviewing the development of the human genome sequencing project in the past 10 years and looking forward to its glorious future worth looking forward to . The following is the main content of the article:

From Bill Clinton to Tony Blair, a 62-page article in 2001 in Nature made the world, including the two, excited about sequencing the human genome, or a little bit excited Too much.

Eric Lander, the first author of this article and the current director of the Broad Institute of MIT and Harvard, said, "People have shown a bit of excessive enthusiasm for sequencing the human genome." Over the past year, the situation remains, "The front page of the news related to the tenth anniversary of the sequencing project is still blaming genomics scientists for not yet able to cure most diseases." For the development of medical care, sequencing in 2001 was only a milestone, not an end point.

Is medical progress really slower than expected at the time? Eric Green and Mark Guyer of the National Human Genome Research Institute believe that "significant changes do not usually come soon", "although In some cases, genomics has begun to make progress in medical diagnosis and treatment, but it is still many years to expect a significant improvement in health care efficiency. " Research alone is not enough. New policies and practices are also necessary.

Sequencing of the human genome is a scientific and technological success in every respect. Some scholars believe that "the continuous development of sequencing technology is making clinical applications for medical diagnosis and treatment possible." A strong proof is the development of genome-wide association studies.

Ten years ago, some people thought that human genome engineering was a great achievement in human history, just like landing on the moon and inventing the wheel. However, it is too early to put genome sequencing into the annals of history. We must achieve greater success on this basis to achieve real success of genome sequencing.

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