A large research team has found that the administration of type 1 interferon to macaques infected with simian immunodeficiency virus (SIV) has both beneficial and deleterious effects.
SIV is a monkey immunodeficiency virus similar to HIV. The latter is the causative virus that causes human AIDS. Shortly after the widespread knowledge of HIV and AIDS in the early 1980s, researchers began using interferon as a drug to help stop the spread of HIV infection into AIDS.
Interferon is a protein produced by the body that responds to pathogens such as parasites, bacteria, viruses and even tumors by releasing interferon. People hope to provide more benefits by adding interferons. Unfortunately, as the research progressed, it was found that there was no benefit in administering interferon to HIV-infected patients and AIDS patients.
In this new study, researchers used interferon as a treatment for monkey-like analogs of HIV. They found that the results of earlier studies so far did not take into account the time given to interferon, so doctors could not see the beneficial effects of interferon in inhibiting disease progression.
In fact, the researchers found two things. The first is that administration of interferon before exposure to SIV in macaques can help prevent interference, and administration of an interferon receptor antagonist can lead to the opposite effect, contributing to a serious infection. Another thing is that they found that it is important to give interferon time to infected monkeys.
The researchers found that monkeys were given interferon at the onset of SIV infection, a protein that actually blocks infection by inhibiting inflammation as part of the immune system response. But giving them interferon after the infection has been established seems to only make things worse.
Therefore, they concluded that interferon may be a valuable treatment for HIV patients, but research is still needed to determine if interferon works in the same way in the human body, and if so, is there a A method to determine when the beneficial phase ends.
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