Artemisia annua, Sexual Ganxin, is a common Chinese medicine. Artemisia annua is a plant of Compositae, which has the effect of clearing heat and relieving heat. Taking a bath with artemisia, you can effectively go to the heat. In addition, what is the effect and role of Artemisia annua? Artemisia annua can also treat diseases such as malaria and jaundice. Let's take a look at the other functions and effects of Artemisia annua.
The role of Artemisia annua
Antipyretic and anti-inflammatory analgesia
The water extract has obvious antipyretic and cooling effects on the fever of rats. It is used together with honeysuckle to make Yinqing injection. The cooling effect is more obvious, the fever is rapid and lasting, and it is superior to the control Bupleurum injection. Water extract has obvious inhibitory effect on inflammation and has certain analgesic effect.
Regulatory immunity
Artemisinin can enhance the phagocytosis of mouse peritoneal macrophages, and increase the lymphocyte transformation rate in animals with low immunity caused by corticosteroids. Artesunate can increase the level of complement in rats. Artemether can significantly reduce serum IgG levels in mice. Artemisinin and artemether have the function of promoting the proliferation of spleen Ts cells, and thus can inhibit IgG. Injecting artemether into the dog's muscle showed a significant decrease in T, B, Tu, and Tr lymphocytes. The above indicates that Artemisia annua L. plays a regulatory role in immune function, enhances non-specific immunity, and plays a two-way regulation on cellular immune function, which inhibits humoral immune function.
Anticancer
Artemisinic acid and its derivatives have cytotoxic effects on various cell lines. It has obvious inhibitory effects on mouse leukemia cell line, human liver cancer cell line, normal human embryo lung cancer cell line and human gastric cancer cell line. Artemisinin and its derivatives also have cytotoxic effects.
Antimalarial
Artemisinin can significantly inhibit the growth of Plasmodium falciparum asexual body and has direct killing effect on Plasmodium. The antimalarial effect of artemisinin and artemether is similar to that of chloroquine. The morphological changes of Plasmodium falciparum are similar to those of chloroquine. The effect of artemisinin is stronger than that of chloroquine. The antimalarial mechanism of Artemisia annua L. mainly affects the function of the membrane-mitochondria. Direct action on Plasmodium can also damage and destroy host red blood cells, leading to the death of Plasmodium.
other
Artemisinin has a broad spectrum of antibacterial, antiviral and antifungal effects; it has a slowing heart rate and antihypertensive effect; it has anti-radiation effects.
In vivo process
Artemisinin is absorbed quickly in the body and distributed to various tissues half an hour after the drug. Excretion is also fast, 84% of the body 8 to 24 hours after the drug is excreted.
Antibacterial effect
Artemisia annua decoction has strong antibacterial activity against Staphylococcus epidermidis, catarrhalis, Bacillus anthracis, and diphtheria bacillus, and also has a certain inhibitory effect on Staphylococcus aureus, Pseudomonas aeruginosa, Shigella, and tuberculosis.
Antiparasitic effect
Artemisia annua L. extract, dilute alcohol extract and artemisinin have significant antimalarial effects on malaria, monkey malaria and human malaria.
Role in the cardiovascular system
Rabbit heart perfusion showed that artemisinin can slow heart rate, inhibit myocardial contractility and reduce coronary flow. Intravenous injection has a blood pressure lowering effect, but does not affect the pressor response of norepinephrine, which is believed to be mainly caused by direct inhibition of the heart. Intravenous injection of 20mg/kg artemisinin can induce arrhythmia in rabbits caused by aconitine.
Clear heat
It is used in the late stage of fever, heat and yin, night heat, cold, heat and no sweat. It is often used in the same way as armor, raw land and Zhimu, such as Artemisia annua soup.
For yin deficiency hot flashes, bone steaming, night sweats, often used with armor, ground bone skin, such as Qin Qin A scattered.
Step 2, clearing heat
It is used for exogenous sensation, fever and no sweat. It can be used in the same way as forsythia, camphor, talc and licorice. If the child is hot in summer, it can be used in the same way as the bone skin, Bai Wei and Zhimu.
Step 3: Heat and dampness
For acute and chronic hepatitis and cholecystitis, often used with jaundice, medlar, pinellia, rhubarb, red peony.
For damp-heat disease, it is often caused by exogenous sensation, internal injury, cold and heat caused by dampness, stagnation of the intestines, abdominal pain, sputum redness, urgency and weight, anus burning, often used with puerarin, astragalus and white lentils.
For rheumatic pain, this product can be used with other rheumatoid drugs.
Step 4 Cool blood to stop bleeding
For nasal sputum, purple spot, treatment of nasal sputum can be used with fresh oyster sauce and boiled water, cure purple spots can be used with rehmannia, red peony, peony bark, angelica.
(3) Health medicated diet
Step 1 Artemisia porridge
Ingredients: 100 grams of fresh artemisia annua (dry product 30 grams), 50 grams of glutinous rice, sugar amount.
Practice: first wash the fresh green artemisia, and smash the drug juice 30 ~ 60 ml. Boiled glutinous rice porridge, after the porridge is cooked, pour the green wormwood juice (the dried product should first be fried, then cook the glutinous rice porridge with juice), add sugar and stir, then boil and take.
Medicinal effect: The porridge has the effect of clearing heat and reducing fever, and is suitable for exogenous fever, yin deficiency fever, and fever of falciparum malaria.
Step 2 Scorpion Artemisia annua steamed turtle
Ingredients: 1 turtle (about 500 grams), 30 grams of medlar, 30 grams of ground bone, 9 grams of Artemisia annua, onion, ginger, wine, crystal sugar.
Practice: first wash the turtle into the internal organs. Put the hazelnuts, onions, ginger, wine, and rock sugar into the belly of the turtle. Use Artemisia annua, Digupi decoction, and take the soup to boil the turtle for 1 hour to eat meat and soup.
Medicinal effect: This product has the effect of nourishing yin and clearing heat, and is effective for patients with low fever and AIDS.
1 Anti-malarial effect: Neutral extract of Artemisia annua L. and its dilute alcohol extract have significant antimalarial effects on malaria, monkey malaria and human malaria. In vivo experiments showed that artemisinin has a killing effect on the intracellular phase of Plasmodium erythrocytes, but not in the extraerythrocytic phase and the early stage of red blood cells. Artemisinin has the effect of rapidly inhibiting the maturation of protozoa. The antimalarial effect of artemether emulsion is better than that of reduced artemisinin sodium succinate, which is an ideal dosage form for the treatment of dangerous malaria.
Artesunate 2.5, 5, 10, 15 mg / kg, 2 times / day, for 3 consecutive days, skin external hemorrhoids, treatment of monkey malaria have different degrees of efficacy. 5, 10mg / kg, 2 times / day, for 10 consecutive days, the skin outside the sputum can make the monkey malaria turn negative. Adding an appropriate amount of atropine can increase the antimalarial effect. The ED50 and ED90 of the decarboxylated artemisinin and the carbon decarboxylated artemisinin in the mouse Plasmodium berghei K173 strain were 12.6 mg/kg and 25.8 mg/kg, respectively.
In vitro tests have shown that artemisinin can significantly inhibit the growth of Plasmodium falciparum asexual body and has direct killing effect. The IC50 of artemisinin, artemether and chloroquine against Plasmodium falciparum were 75.2, 29.4. and 43.2 nmol/L, respectively. Artemisinin sodium inhibited six isolates of Plasmodium falciparum, including anti-chloroquine strains.
2. Antibacterial effect: Artemisia annua decoction has strong antibacterial activity against Staphylococcus epidermidis, catarrhalis, Bacillus anthracis, and diphtheria bacillus, and also has Staphylococcus aureus, Pseudomonas aeruginosa, Shigella, and tuberculosis Certain inhibition. The volatile oil of Artemisia annua L. has a bacteriostatic effect on all dermatophytes at a concentration of 0.25%, and has a bactericidal effect on all dermatophytes at a concentration of 1%.
Artemisinin has an anti-influenza effect. Artemisinin has certain antibacterial effect on golden grape, Shigella flexneri, Escherichia coli, catarrhal bacteria, A and B paratyphoid bacteria. The sitosterol and stigmasterol in Artemisia annua also have antiviral effects.
3. Anti-parasitic effects: Artemisia annua L. extract, dilute alcohol extract and artemisinin have significant antimalarial effects on malaria, monkey malaria and human malaria. In vitro culture suggests that artemisinin has a direct killing effect on Plasmodium. Electron microscopy showed that artemisinin mainly acts on the membrane phase structure of Plasmodium erythrocytes in the endogenous asexual body, first acting on food color film, membrane and mitochondrial membrane, followed by nuclear membrane and endoplasmic reticulum.
In addition, it also affects the chromosomes in the nucleus. Due to changes in the food vesicles, the early stages of the intake of malaria parasites are blocked, causing the rapid development of amino acid starvation of the malaria parasites, the formation of autophagic vacuoles, and continuous excretion, resulting in a large loss of foam and internal structure collapse and death. Artemisinin has the characteristics of high efficacy, fever and rapid decay of protozoa in vivax malaria, falciparum malaria and chloroquine-resistant falciparum malaria. It is especially suitable for the rescue of dangerous malaria, but the re-ignition rate is high. In addition, Artemisia annua has anti-schistosomiasis and leptospira.
4. Antipyretic effect: Artemisia annua injection prepared by distillation method has obvious antipyretic effect on rabbits which are heated by hundred, white and broken triple vaccine. Artemisia annua L. and honeysuckle prescription, the Qingyin injection prepared by distillation method, the rabbits which cause heat to typhoid fever, paratyphoid A and B triple vaccine have more significant antipyretic effect than single-flavored Artemisia annua injection. Its cooling characteristics are rapid and long-lasting, which is superior to the control group of Bupleurum and Antongding injection. Honeysuckle and Artemisia annua have synergistic antipyretic effects.
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The colors of the small bonsai pots are colorful. Among them, the three colors of vermilion, purple and beige are the main colors; during the firing process, as the temperature after entering the kiln is different, the depth and intensity of the color changes more and more; coupled with the accumulation of long-term practical experience of the artists, they use different proportions of mud With the preparation of materials, there are dozens of colors after firing. For example, the colors are named iron blue, sky blue, maroon, begonia red, cinnabar purple, water green, agarwood, sunflower yellow, cold golden color, pear skin, blue gray, dark green, patina, brown black, durian skin and other colors. If you observe carefully, there is a little bit of white sand in the mud, with silver light flashing, and some of the mud is mixed with coarse mud sand or steel sand, and the particles are looming and extremely eye-catching. Although the color changes in the purple sand are many, the tones are very calm. If you plant ancient piles of pine and cypress, it will be more simple and simple.
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